2FM5
Crystal structure of PDE4D2 in complex with inhibitor L-869299
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | polymer | 361 | 41523.9 | 4 | UniProt (Q08499) Pfam (PF00233) In PDB | Homo sapiens (human) | DPDE3, PDE43 |
2 | A, B, C, D | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
3 | A, B, C, D | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
4 | A, B, C, D | (R)-3-(2-(3-CYCLOPROPOXY-4-(DIFLUOROMETHOXY)PHENYL)-2-(5-(1,1,1,3,3,3-HEXAFLUORO-2-HYDROXYPROPAN-2-YL)THIAZOL-2-YL)ETHYL)PYRIDINE 1-OXIDE | non-polymer | 570.5 | 4 | Chemie (M99) | |||
5 | water | water | 18.0 | 345 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 166095.5 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 2640.7 | |
All* | Total formula weight | 168736.2 |