2FLE
Structural analysis of asymmetric inhibitor bound to the HIV-1 Protease V82A mutant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | pol protein | polymer | 99 | 10747.7 | 2 | GenBank (33304696) Pfam (PF00077) UniProt (by SIFTS) (Q9J2R0) In PDB | Human immunodeficiency virus 1 | |
| 2 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 3 | B | (2S,2'S)-N,N'-[(2S,3S,4S,5S)-1-CYCLOHEXYL-3,4-DIHYDROXY-6-PHENYLHEXANE-2,5-DIYL]BIS[3-METHYL-2-({[METHYL(PYRIDIN-2-YLMETHYL)AMINO]CARBONYL}AMINO)BUTANAMIDE] | non-polymer | 801.0 | 1 | Chemie (AI) | |||
| 4 | water | water | 18.0 | 77 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (GenBank: 33304696)
| PDB | External Database | Details |
|---|---|---|
| Ala 82 | Val 88 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21495.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 893.1 | |
| All* | Total formula weight | 22388.5 |
