2FDP
Crystal structure of beta-secretase complexed with an amino-ethylene inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Beta-secretase 1 | polymer | 388 | 43255.8 | 3 | UniProt (P56817) Pfam (PF00026) | Homo sapiens (human) | Beta-site APP cleaving enzyme 1, Beta-site amyloid precursor protein cleaving enzyme 1, Aspartyl protease 2, Asp 2, ASP2, Membrane-associated aspartic protease 2, Memapsin-2 |
| 2 | D, E, F (A, B, C) | N1-((2S,3S,5R)-3-AMINO-6-(4-FLUOROPHENYLAMINO)-5-METHYL-6-OXO-1-PHENYLHEXAN-2-YL)-N3,N3-DIPROPYLISOPHTHALAMIDE | non-polymer | 560.7 | 3 | Chemie (FRP) | |||
| 3 | G, H, I (A, B, C) | water | water | 18.0 | 100 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 129767.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1682.1 | |
| All* | Total formula weight | 131449.4 |
