2FDD
Crystal structure of HIV protease D545701 bound with GW0385
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Gag-Pol polyprotein | polymer | 100 | 10914.8 | 2 | GenBank (P03368) Pfam (PF00077) UniProt (by SIFTS) (Q7SPG9) | Human immunodeficiency virus 1 | |
| 2 | C (B) | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL [(1S,2R)-3-[(1,3-BENZODIOXOL-5-YLSULFONYL)(ISOBUTYL)AMINO]-2-HYDROXY-1-{4-[(2-METHYL-1,3-THIAZOL-4-YL)METHOXY]BENZYL}PROPYL]CARBAMATE | non-polymer | 703.8 | 1 | Chemie (385) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 302 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (GenBank: P03368)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Ile 10 | Leu 509 | engineered mutation |
| Gln 19 | Leu 518 | engineered mutation |
| Arg 20 | Lys 519 | engineered mutation |
| Asp 35 | Glu 534 | engineered mutation |
| Ile 36 | Met 535 | engineered mutation |
| Asn 37 | Ser 536 | engineered mutation |
| Ile 46 | Met 545 | engineered mutation |
| Val 50 | Ile 549 | engineered mutation |
| Val 54 | Ile 553 | engineered mutation |
| Val 62 | Ile 561 | engineered mutation |
| Pro 63 | Leu 562 | engineered mutation |
| Val 71 | Ala 570 | engineered mutation |
| Ala 82 | Val 581 | engineered mutation |
| Met 90 | Leu 589 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21829.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 703.8 | |
| All* | Total formula weight | 22533.4 |
