2F9U
HCV NS3 protease domain with NS4a peptide and a ketoamide inhibitor with a P2 norborane
エンティティ
| Entity ID | 鎖名 | 説明 | 種類 | 鎖長 | 化学式量 | 分子数 | データベース名(アクセス番号) | 由来する生物種 | エンティティの一般名 |
| 1 | A, C | NS3 protease/helicase' | polymer | 199 | 21102.0 | 2 | UniProt (Q91RS4) Pfam (PF02907) In PDB | Hepatitis C virus | |
| 2 | B, D | polyprotein | polymer | 23 | 2394.0 | 2 | GenBank (51039195) | ||
| 3 | A, C | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | A | 1,1-DIMETHYLETHYL [1-CYCLOHEXYL-2-[3-[[[1-[2-[[2-[[2-(DIMETHYLAMINO)-2-OXO-1-PHENYLETHYL]AMINO]-2-OXOETHYL]AMINO]-1,2-DIOXOETHYL]PENTYL]AMINO]CARBONYL]-2-AZABICYCLO[2.2.1]HEPTAN-2-YL]-2-OXOETHYL]CARBAMATE | non-polymer | 738.9 | 1 | Chemie (5NH) | |||
| 5 | water | water | 18.0 | 115 | Chemie (HOH) |
配列変更
A, C: 1 - 181 (UniProt: Q91RS4)
B, D: 21 - 39 (GenBank: 51039195)
| PDB | 外部データベース | 詳細 |
|---|---|---|
| Ala -9 | - | cloning artifact |
| Ser -8 | - | cloning artifact |
| Met -7 | - | cloning artifact |
| Thr -6 | - | cloning artifact |
| Gly -5 | - | cloning artifact |
| Gly -4 | - | cloning artifact |
| Gln -3 | - | cloning artifact |
| Gln -2 | - | cloning artifact |
| Met -1 | - | cloning artifact |
| Gly 0 | - | cloning artifact |
| Gly 182 | - | cloning artifact |
| Ser 183 | - | cloning artifact |
| His 184 | - | expression tag |
| His 185 | - | expression tag |
| His 186 | - | expression tag |
| His 187 | - | expression tag |
| His 188 | - | expression tag |
| His 189 | - | expression tag |
| PDB | 外部データベース | 詳細 |
|---|---|---|
| Lys 19 | - | cloning artifact |
| Lys 20 | - | cloning artifact |
| Ser 22 | Cys 576 | engineered mutation |
| Lys 40 | - | cloning artifact |
| Lys 41 | - | cloning artifact |
配列ビューア
非対称単位の内容
| タンパク質・ 核酸鎖 | 鎖の数 | 4 |
| 化学式量合計 | 46992.1 | |
| タンパク質・ 核酸・ 糖鎖以外* | 分子数 | 3 |
| 化学式量合計 | 869.7 | |
| 全て* | 化学式量合計 | 47861.9 |
