2F2U
crystal structure of the Rho-kinase kinase domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Rho-associated protein kinase 2 | polymer | 402 | 45776.0 | 2 | UniProt (Q28021) Pfam (PF00069) | Bos taurus (cattle) | Rho-associated, coiled- coil containing protein kinase 2, p164 ROCK-2 |
| 2 | C, D (A, B) | 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE | non-polymer | 291.4 | 2 | Chemie (M77) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 162 | Chemie (HOH) |
Sequence modifications
A, B: 18 - 417 (UniProt: Q28021)
| PDB | External Database | Details |
|---|---|---|
| Gly 16 | - | cloning artifact |
| Ala 17 | - | cloning artifact |
| Ser 52 | Pro 52 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 91552.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 582.7 | |
| All* | Total formula weight | 92134.8 |
