2F0Y
Crystal Structure Of Human Protein Farnesyltransferase Complexed With Farnesyl Diphosphate and hydantoin derivative
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit | polymer | 379 | 44459.4 | 1 | UniProt (P49354) Pfam (PF01239) In PDB | Homo sapiens (human) | CAAX farnesyltransferase alpha subunit, Ras proteins prenyltransferase alpha, FTase-alpha, Type I protein geranyl-geranyltransferase alpha subunit, GGTase-I-alpha |
| 2 | B | Protein farnesyltransferase beta subunit | polymer | 437 | 48822.4 | 1 | UniProt (P49356) Pfam (PF00432) In PDB | Homo sapiens (human) | CAAX farnesyltransferase beta subunit, RAS proteins prenyltransferase beta, FTase-beta |
| 3 | B | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | B | FARNESYL DIPHOSPHATE | non-polymer | 382.3 | 1 | Chemie (FPP) | |||
| 5 | B | 3-({3-[3-(1H-IMIDAZOL-1-YL)PROPYL]-5-METHYL-5-(1-NAPHTHYL)-2,4-DIOXOIMIDAZOLIDIN-1-YL}METHYL)BENZONITRILE | non-polymer | 463.5 | 1 | Chemie (3MN) | |||
| 6 | water | water | 18.0 | 409 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 93281.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 911.3 | |
| All* | Total formula weight | 94193.1 |
