2EX4

Crystal Structure of Human methyltransferase AD-003 in complex with S-adenosyl-L-homocysteine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	adrenal gland protein AD-003	polymer	241	27320.1	2	UniProt (Q9BV86) Pfam (PF05891) In PDB	Homo sapiens (human)
2	A, B	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	2	Chemie (SAH)
3		water	water		18.0	555	Chemie (HOH)

Sequence modifications

A, B: 2 - 223 (UniProt: Q9BV86)

PDB	External Database	Details
Met -17	-	cloning artifact
Gly -16	-	cloning artifact
Ser -15	-	cloning artifact
Ser -14	-	cloning artifact
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
Ser -7	-	cloning artifact
Ser -6	-	cloning artifact
Gly -5	-	cloning artifact
Leu -4	-	cloning artifact
Val -3	-	cloning artifact
Pro -2	-	cloning artifact
Arg -1	-	cloning artifact
Gly 0	-	cloning artifact
Ser 1	-	cloning artifact
-	Ser 38	deletion

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	54640.1
Non-Polymers*	Number of molecules	2
	Total formula weight	768.8
All*	Total formula weight	55409.0

*Water molecules are not included.