2EGH
Crystal structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase complexed with a magnesium ion, NADPH and fosmidomycin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | polymer | 424 | 46173.9 | 2 | UniProt (P45568) Pfam (PF02670) Pfam (PF08436) Pfam (PF13288) In PDB | Escherichia coli str. K12 substr. | DXP reductoisomerase, 1-deoxyxylulose-5-phosphate reductoisomerase, 2-C- methyl-D-erythritol 4-phosphate synthase |
| 2 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 3 | A, B | 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID | non-polymer | 183.1 | 2 | Chemie (FOM) | |||
| 4 | A, B | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
| 5 | water | water | 18.0 | 301 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 397 (UniProt: P45568)
| PDB | External Database | Details |
|---|---|---|
| Met -10 | - | cloning artifact |
| Arg -9 | - | cloning artifact |
| Gly -8 | - | cloning artifact |
| Ser -7 | - | cloning artifact |
| His -6 | - | cloning artifact |
| His -5 | - | cloning artifact |
| His -4 | - | cloning artifact |
| His -3 | - | cloning artifact |
| His -2 | - | cloning artifact |
| His -1 | - | cloning artifact |
| Gly 0 | - | cloning artifact |
| Ser 398 | - | cloning artifact |
| Ala 399 | - | cloning artifact |
| Cys 400 | - | cloning artifact |
| Asp 401 | - | cloning artifact |
| Leu 402 | - | cloning artifact |
| Gly 403 | - | cloning artifact |
| Thr 404 | - | cloning artifact |
| Pro 405 | - | cloning artifact |
| Gly 406 | - | cloning artifact |
| Arg 407 | - | cloning artifact |
| Pro 408 | - | cloning artifact |
| Ala 409 | - | cloning artifact |
| Ala 410 | - | cloning artifact |
| Lys 411 | - | cloning artifact |
| Leu 412 | - | cloning artifact |
| Asn 413 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 92347.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1905.7 | |
| All* | Total formula weight | 94253.4 |
