2E5C
Crystal structure of Human NMPRTase complexed with 5'-phosphoribosyl-1'-pyrophosphate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Nicotinamide phosphoribosyltransferase | polymer | 499 | 56378.8 | 2 | UniProt (P43490) Pfam (PF18127) Pfam (PF04095) | Homo sapiens (human) | NAmPRTase, Nampt, Pre-B cell-enhancing factor, Pre-B-cell colony-enhancing factor 1, Visfatin |
| 2 | C, D (A, B) | 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose | non-polymer | 390.1 | 2 | Chemie (PRP) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 782 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 491 (UniProt: P43490)
| PDB | External Database | Details |
|---|---|---|
| Gly -7 | - | expression tag |
| Pro -6 | - | expression tag |
| Leu -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Pro -2 | - | expression tag |
| Gln -1 | - | expression tag |
| Phe 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 112757.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 780.1 | |
| All* | Total formula weight | 113537.8 |
