2E4V
Crystal structure of the extracellular region of the group II metabotropic glutamate receptor complexed with DCG-IV
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Metabotropic glutamate receptor 3 | polymer | 555 | 63117.3 | 2 | UniProt (P31422) Pfam (PF01094) Pfam (PF07562) | Rattus norvegicus (Norway rat) | mGluR3, group II metabotropic glutamate receptor subtype 3 |
| 2 | C, E (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 3 | D, F (A, B) | (1R,2R)-3-[(S)-amino(carboxy)methyl]cyclopropane-1,2-dicarboxylic acid | non-polymer | 203.1 | 2 | Chemie (2CG) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 345 | Chemie (HOH) |
Sequence modifications
A, B: 25 - 575 (UniProt: P31422)
| PDB | External Database | Details |
|---|---|---|
| Gln 414 | Asn 414 | engineered mutation |
| Gln 439 | Asn 439 | engineered mutation |
| Leu 576 | - | cloning artifact |
| Val 577 | - | cloning artifact |
| Pro 578 | - | cloning artifact |
| Arg 579 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 126234.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 848.7 | |
| All* | Total formula weight | 127083.3 |
