2E2D
Flexibility and variability of TIMP binding: X-ray structure of the complex between collagenase-3/MMP-13 and TIMP-2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Matrix metallopeptidase 13 | polymer | 165 | 18607.8 | 1 | UniProt (P45452) Pfam (PF00413) In PDB | Homo sapiens (human) | MMP-13; Collagenase-3 |
| 2 | C | Metalloproteinase inhibitor 2 | polymer | 180 | 20192.3 | 1 | UniProt (P16368) Pfam (PF00965) In PDB | Bos taurus (cattle) | TIMP-2; Tissue inhibitor of metalloproteinases 2; Collagenase inhibitor |
| 3 | A | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | A | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 5 | water | water | 18.0 | 323 | Chemie (HOH) |
Sequence modifications
C: 1002 - 1180 (UniProt: P16368)
| PDB | External Database | Details |
|---|---|---|
| Cys 1001 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 38800.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 211.0 | |
| All* | Total formula weight | 39011.1 |
