2E2B
Crystal structure of the c-Abl kinase domain in complex with INNO-406
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Proto-oncogene tyrosine-protein kinase ABL1 | polymer | 293 | 33739.5 | 2 | UniProt (P00519) Pfam (PF07714) In PDB | Homo sapiens (human) | p150, c-ABL, Abelson murine leukemia viral oncogene homolog 1 |
| 2 | A, B | N-[3-(4,5'-BIPYRIMIDIN-2-YLAMINO)-4-METHYLPHENYL]-4-{[(3S)-3-(DIMETHYLAMINO)PYRROLIDIN-1-YL]METHYL}-3-(TRIFLUOROMETHYL) BENZAMIDE | non-polymer | 576.6 | 2 | Chemie (406) | |||
| 3 | water | water | 18.0 | 135 | Chemie (HOH) |
Sequence modifications
A, B: 229 - 515 (UniProt: P00519)
| PDB | External Database | Details |
|---|---|---|
| Gly 223 | - | cloning artifact |
| Ala 224 | - | cloning artifact |
| Met 225 | - | cloning artifact |
| Asp 226 | - | cloning artifact |
| Pro 227 | - | cloning artifact |
| Ser 228 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 67479.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1153.2 | |
| All* | Total formula weight | 68632.2 |
