2DYL
Crystal structure of human mitogen-activated protein kinase kinase 7 activated mutant (S287D, T291D)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dual specificity mitogen-activated protein kinase kinase 7 | polymer | 318 | 35760.3 | 1 | UniProt (O14733) Pfam (PF00069) | Homo sapiens (human) | mitogen-activated protein kinase kinase 7 gamma 1, MAP kinase kinase 7, MAPKK 7, MAPK/ERK kinase 7, JNK-activating kinase 2, c-Jun N-terminal kinase kinase 2, JNK kinase 2, JNKK 2 |
| 2 | B (A) | water | water | 18.0 | 37 | Chemie (HOH) |
Sequence modifications
A: 117 - 421 (UniProt: O14733)
| PDB | External Database | Details |
|---|---|---|
| Gly 110 | - | expression tag |
| Ser 111 | - | expression tag |
| Ser 112 | - | expression tag |
| Gly 113 | - | expression tag |
| Ser 114 | - | expression tag |
| Ser 115 | - | expression tag |
| Gly 116 | - | expression tag |
| Asp 287 | Ser 271 | engineered mutation |
| Asp 291 | Thr 275 | engineered mutation |
| Ser 422 | - | expression tag |
| Gly 423 | - | expression tag |
| Pro 424 | - | expression tag |
| Ser 425 | - | expression tag |
| Ser 426 | - | expression tag |
| Gly 427 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35760.3 | |
| All* | Total formula weight | 35760.3 |
