2DS1
Human cyclin dependent kinase 2 complexed with the CDK4 inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cell division protein kinase 2 | polymer | 298 | 33925.4 | 1 | UniProt (P24941) Pfam (PF00069) | Homo sapiens (human) | p33 protein kinase |
| 2 | B (A) | (13R,15S)-13-METHYL-16-OXA-8,9,12,22,24-PENTAAZAHEXACYCLO[15.6.2.16,9.1,12,15.0,2,7.0,21,25]HEPTACOSA-1(24),2,4,6,17(25 ),18,20-HEPTAENE-23,26-DIONE | non-polymer | 403.4 | 1 | Chemie (1CD) | |||
| 3 | C (A) | water | water | 18.0 | 140 | Chemie (HOH) |
Sequence modifications
A: 1 - 298 (UniProt: P24941)
| PDB | External Database | Details |
|---|---|---|
| His 82 | Phe 82 | engineered mutation |
| Val 83 | Leu 83 | engineered mutation |
| Thr 89 | Lys 89 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33925.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 403.4 | |
| All* | Total formula weight | 34328.8 |
