2DQZ
Crystal structure of human carboxylesterase in complex with homatropine, coenzyme A, and palmitate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C | Liver carboxylesterase 1 | polymer | 542 | 59787.5 | 3 | UniProt (P23141) Pfam (PF00135) In PDB | Homo sapiens (human) | Acyl coenzyme A:cholesterol acyltransferase, ACAT, Monocyte/macrophage serine esterase, HMSE, Serine esterase 1, Brain carboxylesterase hBr1, Triacylglycerol hydrolase, TGH, Egasyn |
| 2 | A, B, C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 3 | A, B, C | N-acetyl-alpha-neuraminic acid | non-polymer | 309.3 | 3 | Chemie (SIA) | |||
| 4 | A, B, C | SULFATE ION | non-polymer | 96.1 | 7 | Chemie (SO4) | |||
| 5 | A, B, C | FLUORIDE ION | non-polymer | 19.0 | 3 | Chemie (F) | |||
| 6 | A, B, C | PALMITIC ACID | non-polymer | 256.4 | 3 | Chemie (PLM) | |||
| 7 | A, B, C | HOMOTROPINE | non-polymer | 275.3 | 3 | Chemie (HTQ) | |||
| 8 | C | COENZYME A | non-polymer | 767.5 | 1 | Chemie (COA) | |||
| 9 | water | water | 18.0 | 508 | Chemie (HOH) |
Sequence modifications
A, B, C: 1019 - 1561 (UniProt: P23141)
| PDB | External Database | Details |
|---|---|---|
| - | Gln 362 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 179362.6 | |
| Non-Polymers* | Number of molecules | 23 |
| Total formula weight | 4683.7 | |
| All* | Total formula weight | 184046.3 |
