2DG4
FK506-binding protein mutant WF59 complexed with Rapamycin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | FK506-binding protein 1A | polymer | 107 | 11797.5 | 1 | UniProt (P62942) Pfam (PF00254) | Homo sapiens (human) | Peptidyl-prolyl cis-trans isomerase, PPIase, Rotamase, 12 kDa FKBP, FKBP-12, Immunophilin FKBP12 |
| 2 | B (A) | RAPAMYCIN IMMUNOSUPPRESSANT DRUG | non-polymer | 914.2 | 1 | Chemie (RAP) | |||
| 3 | C (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | D (A) | water | water | 18.0 | 153 | Chemie (HOH) |
Sequence modifications
A: 1 - 107 (UniProt: P62942)
| PDB | External Database | Details |
|---|---|---|
| Phe 59 | Trp 60 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 11797.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1006.3 | |
| All* | Total formula weight | 12803.7 |
