2D26
Active site distortion is sufficient for proteinase inhibit second crystal structure of covalent serpin-proteinase complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Alpha-1-antitrypsin | polymer | 358 | 40115.3 | 1 | UniProt (P01009) Pfam (PF00079) | Homo sapiens (human) | Alpha-1 protease inhibitor, Alpha-1- antiproteinase |
| 2 | B (B) | Alpha-1-antitrypsin | polymer | 36 | 4133.9 | 1 | UniProt (P01009) | Homo sapiens (human) | Alpha-1 protease inhibitor, Alpha-1- antiproteinase |
| 3 | C (C) | Elastase-1 | polymer | 240 | 25929.0 | 1 | UniProt (P00772) Pfam (PF00089) | Sus scrofa (pig) | |
| 4 | D, E, F (A, B, C) | water | water | 18.0 | 75 | Chemie (HOH) |
Sequence modifications
A: 1 - 358 (UniProt: P01009)
B: 359 - 394 (UniProt: P01009)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | Glu 25 | engineered mutation |
| Leu 51 | Phe 75 | engineered mutation |
| Ala 59 | Thr 83 | engineered mutation |
| Ala 68 | Thr 92 | engineered mutation |
| Gly 70 | Ala 94 | engineered mutation |
| His 101 | Arg 125 | engineered mutation |
| Ser 232 | Cys 256 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ile 374 | Met 398 | engineered mutation |
| Ala 381 | Ser 405 | engineered mutation |
| Arg 387 | Lys 411 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 70178.3 | |
| All* | Total formula weight | 70178.3 |
