2CVD
Crystal structure analysis of human hematopoietic prostaglandin D synthase complexed with HQL-79
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Glutathione-requiring prostaglandin D synthase | polymer | 198 | 23256.7 | 4 | UniProt (O60760) Pfam (PF02798) Pfam (PF14497) | Homo sapiens (human) | Glutathione-dependent PGD synthetase, Prostaglandin-H2 D-isomerase, Hematopoietic prostaglandin D synthase, H-PGDS |
| 2 | E, I (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 3 | F, J, N, T (A, B, C, D) | GLUTATHIONE | non-polymer | 307.3 | 4 | Chemie (GSH) PubChem (124886) PubChem (445616) PubChem (448041) PubChem (54289881) PubChem (59012062) PubChem (745) PubChem (9839547) PubChem (10924820) PubChem (15559593) | |||
| 4 | G, K, O, U (A, B, C, D) | 4-(BENZHYDRYLOXY)-1-[3-(1H-TETRAAZOL-5-YL)PROPYL]PIPERIDINE | non-polymer | 377.5 | 4 | Chemie (HQL) | |||
| 5 | H, L, M, P, Q... (A, B, C) | GLYCEROL | non-polymer | 92.1 | 7 | Chemie (GOL) PubChem (753) | |||
| 6 | V, W, X, Y (A, B, C, D) | water | water | 18.0 | 1384 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 2 - 199 (UniProt: O60760)
| PDB | External Database | Details |
|---|---|---|
| Met 144 | Asn 143 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 93026.9 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 3432.5 | |
| All* | Total formula weight | 96459.4 |
