2CMC

Structural Basis for Inhibition of Protein Tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1	polymer	304	35549.4	1	UniProt (P18031) Pfam (PF00102) In PDB	HOMO SAPIENS (HUMAN)	PROTEIN TYROSINE PHOSPHATASE 1B
2	A	N-ACETYL-L-PHENYLALANYL-4-[DIFLUORO(PHOSPHONO)METHYL]-L-PHENYLALANINAMIDE	non-polymer		483.4	1	Chemie (DFM)
3	A	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
4	A	octyl beta-D-glucopyranoside	non-polymer		292.4	1	Chemie (BOG)
5		water	water		18.0	178	Chemie (HOH)

Sequence modifications

A: -5 - -5 (UniProt: P18031)
A: 2 - 298 (UniProt: P18031)
A: -4 - 1 (PDB: 2CMC)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	35549.4
Non-Polymers*	Number of molecules	3
	Total formula weight	871.8
All*	Total formula weight	36421.3

*Water molecules are not included.