2CJY
Extended substrate recognition in caspase-3 revealed by high resolution X-ray structure analysis
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | CASPASE-3 | polymer | 147 | 16639.9 | 1 | UniProt (P42574) Pfam (PF00656) In PDB | HOMO SAPIENS (HUMAN) | CASP-3, APOPAIN, CYSTEINE PROTEASE CPP32, CPP-32, PROTEIN YAMA, SREBP CLEAVAGE ACTIVITY 1, SCA-1, CASPASE-3 SUBUNIT P17, CASPASE-3 SUBUNIT P12 |
2 | B | CASPASE-3 | polymer | 103 | 11981.7 | 1 | UniProt (P42574) Pfam (PF00656) In PDB | HOMO SAPIENS (HUMAN) | CASP-3, APOPAIN, CYSTEINE PROTEASE CPP32, CPP-32, PROTEIN YAMA, SREBP CLEAVAGE ACTIVITY 1, SCA-1, CASPASE-3 SUBUNIT P17, CASPASE-3 SUBUNIT P12 |
3 | I | PHQ-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE | polymer | 6 | 661.5 | 1 | BIRD (PRD_000277) | SYNTHETIC CONSTRUCT | Z-DEVD-CMK |
4 | water | water | 18.0 | 337 | Chemie (HOH) |
Sequence modifications
B: 176 - 277 (UniProt: P42574)
PDB | External Database | Details |
---|---|---|
Ala 175 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 29283.1 | |
All* | Total formula weight | 29283.1 |