2CCI
Crystal structure of phospho-CDK2 Cyclin A in complex with a peptide containing both the substrate and recruitment sites of CDC6
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Cyclin-dependent kinase 2 | polymer | 299 | 34143.5 | 2 | UniProt (P24941) Pfam (PF00069) In PDB | Homo sapiens (Human) | Cell division protein kinase 2,p33 protein kinase |
2 | B, D | Cyclin-A2 | polymer | 258 | 29624.3 | 2 | UniProt (P20248) Pfam (PF00134) Pfam (PF02984) In PDB | Homo sapiens (Human) | Cyclin-A,Cyclin A |
3 | F, I | Cell division control protein 6 homolog | polymer | 30 | 3440.9 | 2 | UniProt (Q99741) In PDB | Homo sapiens | CDC6-related protein,Cdc18-related protein,HsCdc18,p62(cdc6),HsCDC6 |
4 | A, C | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
5 | A, C | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
6 | water | water | 18.0 | 111 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 298 (UniProt: P24941)
F, I: 67 - 96 (UniProt: Q99741)
PDB | External Database | Details |
---|---|---|
Ser 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
His 67 | Pro 71 | engineered mutation |
His 68 | Pro 72 | engineered mutation |
Ala 69 | Cys 73 | engineered mutation |
Arg 72 | Pro 76 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 134417.5 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1063.0 | |
All* | Total formula weight | 135480.5 |