2CCI

Crystal structure of phospho-CDK2 Cyclin A in complex with a peptide containing both the substrate and recruitment sites of CDC6

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Cyclin-dependent kinase 2	polymer	299	34143.5	2	UniProt (P24941) Pfam (PF00069)	Homo sapiens (Human)	Cell division protein kinase 2,p33 protein kinase
2	B, D (B, D)	Cyclin-A2	polymer	258	29624.3	2	UniProt (P20248) Pfam (PF00134) Pfam (PF02984)	Homo sapiens (Human)	Cyclin-A,Cyclin A
3	E, F (F, I)	Cell division control protein 6 homolog	polymer	30	3440.9	2	UniProt (Q99741)	Homo sapiens	CDC6-related protein,Cdc18-related protein,HsCdc18,p62(cdc6),HsCDC6
4	G, I (A, C)	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	2	Chemie (ATP)
5	H, J (A, C)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
6	K, L, M, N, O... (A, B, C, D, F...)	water	water		18.0	111	Chemie (HOH)

Sequence modifications

A, C: 1 - 298 (UniProt: P24941)

PDB	External Database	Details
Ser 0	-	expression tag

F, I: 67 - 96 (UniProt: Q99741)

PDB	External Database	Details
His 67	Pro 71	engineered mutation
His 68	Pro 72	engineered mutation
Ala 69	Cys 73	engineered mutation
Arg 72	Pro 76	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	134417.5
Non-Polymers*	Number of molecules	4
	Total formula weight	1063.0
All*	Total formula weight	135480.5

*Water molecules are not included.