2CBQ
Crystal structure of the neocarzinostatin 1Tes15 mutant bound to testosterone hemisuccinate.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | NEOCARZINOSTATIN | polymer | 114 | 11329.3 | 6 | UniProt (P0A3R9) | STREPTOMYCES CARZINOSTATICUS | NCS, MITOMALCIN, MMC |
| 2 | G, J, M, P, R (A, B, C, E, F) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 3 | H, I, K, L, N... (A, B, C, D, E...) | TESTOSTERONE HEMISUCCINATE | non-polymer | 388.5 | 8 | Chemie (TH2) PubChem (16395642) PubChem (21119834) PubChem (1761053) PubChem (119202) PubChem (248933) PubChem (57367994) PubChem (7076010) PubChem (580175) PubChem (11872510) PubChem (11872512) PubChem (11872514) PubChem (99568890) PubChem (124867314) PubChem (124898307) PubChem (166888263) | |||
| 4 | T, U, V, W, X... (A, B, C, D, E...) | water | water | 18.0 | 87 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 1 - 113 (UniProt: P0A3R9)
A, B, C, D, E, F: 114 - 114 (PDB: 2CBQ)
| PDB | External Database | Details |
|---|---|---|
| Trp 33 | Asp 67 | engineered mutation |
| Tyr 35 | Gly 69 | engineered mutation |
| Arg 37 | Cys 71 | engineered mutation |
| Ala 39 | Trp 73 | engineered mutation |
| His 45 | Leu 79 | engineered mutation |
| Ser 47 | Cys 81 | engineered mutation |
| Leu 52 | Phe 86 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 67975.6 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 3588.3 | |
| All* | Total formula weight | 71563.9 |
