2CBO
Crystal structure of the neocarzinostatin 3Tes24 mutant bound to testosterone hemisuccinate.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NEOCARZINOSTATIN | polymer | 115 | 11615.6 | 1 | UniProt (P0A3R9) Pfam (PF00960) | STREPTOMYCES CARZINOSTATICUS | NCS, MITOMALCIN, MMC |
| 2 | B (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 3 | C, D (A) | TESTOSTERONE HEMISUCCINATE | non-polymer | 388.5 | 2 | Chemie (TH2) | |||
| 4 | E (A) | water | water | 18.0 | 116 | Chemie (HOH) |
Sequence modifications
A: 1 - 113 (UniProt: P0A3R9)
A: 114 - 115 (PDB: 2CBO)
| PDB | External Database | Details |
|---|---|---|
| Trp 33 | Asp 67 | engineered mutation |
| Ala 35 | Gly 69 | engineered mutation |
| Trp 37 | Cys 71 | engineered mutation |
| Arg 39 | Trp 73 | engineered mutation |
| Trp 45 | Leu 79 | engineered mutation |
| Tyr 47 | Cys 81 | engineered mutation |
| Asn 52 | Phe 86 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 11615.6 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 873.1 | |
| All* | Total formula weight | 12488.6 |
