2C73

Functional Role of the Aromatic Cage in Human Monoamine Oxidase B: Structures and Catalytic Properties of Tyr435 Mutant Proteins

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	AMINE OXIDASE (FLAVIN-CONTAINING) B	polymer	520	58821.7	2	UniProt (P27338) Pfam (PF01593)	HOMO SAPIENS (HUMAN)	MONOAMINE OXIDASE B, MAO-B
2	C, E (A, B)	FLAVIN-ADENINE DINUCLEOTIDE	non-polymer		785.5	2	Chemie (FAD)
3	D, F (A, B)	N-PROPARGYL-1(S)-AMINOINDAN	non-polymer		171.2	2	Chemie (RSA)
4	G, H (A, B)	water	water		18.0	315	Chemie (HOH)

Sequence modifications

A, B: 1 - 1 (PDB: 2C73)
A, B: 2 - 520 (UniProt: P27338)

PDB	External Database	Details
Phe 435	Tyr 434	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	117643.5
Non-Polymers*	Number of molecules	4
	Total formula weight	1913.6
All*	Total formula weight	119557.0

*Water molecules are not included.