2C6E

Aurora A kinase activated mutant (T287D) in complex with a 5- aminopyrimidinyl quinazoline inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	SERINE/THREONINE-PROTEIN KINASE 6	polymer	283	32772.6	2	UniProt (O14965) Pfam (PF00069)	HOMO SAPIENS (HUMAN)	AURORA A KINASE, SERINE/THREONINE KINASE 15, AURORA/IPL1-RELATED KINASE 1, AURORA-RELATED KINASE 1, HARK1, AURORA-A, BREAST-TUMOR-AMPLIFIED KINASE
2	C, D (A, B)	N-{5-[(7-{[(2S)-2-HYDROXY-3-PIPERIDIN-1-YLPROPYL]OXY}-6-METHOXYQUINAZOLIN-4-YL)AMINO]PYRIMIDIN-2-YL}BENZAMIDE	non-polymer		529.6	2	Chemie (HPM)
3	E, F (A, B)	water	water		18.0	102	Chemie (HOH)

Sequence modifications

A, B: 118 - 121 (PDB: 2C6E)
A, B: 122 - 400 (UniProt: O14965)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	65545.2
Non-Polymers*	Number of molecules	2
	Total formula weight	1059.2
All*	Total formula weight	66604.4

*Water molecules are not included.