2C5X

Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	CELL DIVISION PROTEIN KINASE 2	polymer	298	33976.5	2	UniProt (P24941) Pfam (PF00069)	HOMO SAPIENS (HUMAN)	CYCLIN DEPENDENT KINASE 2, P33 PROTEIN KINASE
2	B, D (B, D)	CYCLIN A2	polymer	259	29753.4	2	UniProt (P20248) Pfam (PF00134) Pfam (PF02984)	HOMO SAPIENS (HUMAN)	CYCLIN A
3	E, F (A, C)	HYDROXY(OXO)(3-{[(2Z)-4-[3-(1H-1,2,4-TRIAZOL-1-YLMETHYL)PHENYL]PYRIMIDIN-2(5H)-YLIDENE]AMINO}PHENYL)AMMONIUM	non-polymer		373.4	2	Chemie (MTW)
4	G, H, I, J (A, B, C, D)	water	water		18.0	88	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	127459.8
Non-Polymers*	Number of molecules	2
	Total formula weight	746.7
All*	Total formula weight	128206.5

*Water molecules are not included.