2C5V

Differential Binding Of Inhibitors To Active And Inactive Cdk2 Provides Insights For Drug Design

Replaces:  1OKU

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	CELL DIVISION PROTEIN KINASE 2	polymer	298	33976.5	2	UniProt (P24941) Pfam (PF00069)	HOMO SAPIENS (HUMAN)	CYCLIN-DEPENDENT KINASE 2, P33 PROTEIN KINASE
2	B, D (B, D)	CYCLIN A2	polymer	259	29753.4	2	UniProt (P20248) Pfam (PF00134) Pfam (PF02984)	HOMO SAPIENS (HUMAN)	CYCLIN A
3	E, F (F, H)	ALA-ALA-ABA-ARG-SER-LEU-ILE-PFF-NH2	polymer	9	879.0	2		SYNTHETIC CONSTRUCT
4	G, H (A, C)	4-(2,4-DIMETHYL-1,3-THIAZOL-5-YL)-N-[4-(TRIFLUOROMETHYL)PHENYL]PYRIMIDIN-2-AMINE	non-polymer		350.4	2	Chemie (CK4)
5	I, J, K, L, M... (A, B, C, D, F...)	water	water		18.0	188	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	129217.9
Non-Polymers*	Number of molecules	2
	Total formula weight	700.7
All*	Total formula weight	129918.6

*Water molecules are not included.