2C2T
Human Dihydrofolate Reductase Complexed With NADPH and 2,4-Diamino-5-((7,8-dicarbaundecaboran-7-yl)methyl)-6-methylpyrimidine, a novel boron containing, nonclassical Antifolate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | DIHYDROFOLATE REDUCTASE | polymer | 186 | 21349.5 | 2 | UniProt (P00374) Pfam (PF00186) | HOMO SAPIENS (HUMAN) | |
| 2 | C, F (A, B) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
| 3 | D, E, G, H (A, B) | (S)-2,4-DIAMINO-5-((7,8-DICARBAUNDECABORAN-7-YL)METHYL)-6-METHYLPYRIMIDINE | non-polymer | 258.5 | 4 | Chemie (39B) | |||
| 4 | I (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | J, K (A, B) | water | water | 18.0 | 607 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 42699.1 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2616.9 | |
| All* | Total formula weight | 45315.9 |
