2C0O

Src family kinase Hck with bound inhibitor A-770041

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	TYROSINE-PROTEIN KINASE HCK	polymer	454	52000.2	2	UniProt (P08631) Pfam (PF00018) Pfam (PF00017) Pfam (PF07714)	HOMO SAPIENS (HUMAN)	HAEMATOPOETIC CELL KINASE HCK, P59-HCK/P60-HCK HEMOPOIETIC CELL KINASE
2	C, E (A, B)	N-(4-{1-[4-(4-ACETYLPIPERAZIN-1-YL)-TRANS-CYCLOHEXYL]-4-AMINO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL}-2-METHOXYPHENYL)-1-METHYL-1H-INDOLE-2-CARBOXAMIDE	non-polymer		621.7	2	Chemie (L2G)
3	D, F (A, B)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
4	G, H (A, B)	water	water		18.0	248	Chemie (HOH)

Sequence modifications

A, B: 52 - 59 (PDB: 2C0O)
A, B: 60 - 505 (UniProt: P08631)

PDB	External Database	Details
Glu 502	Gln 522	engineered mutation
Glu 503	Gln 523	engineered mutation
Ile 504	Gln 524	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	104000.5
Non-Polymers*	Number of molecules	4
	Total formula weight	1323.6
All*	Total formula weight	105324.1

*Water molecules are not included.