2BQZ

Crystal structure of a ternary complex of the human histone methyltransferase Pr-SET7 (also known as SET8)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, E)	SET8 PROTEIN	polymer	161	18386.8	2	UniProt (Q86W83) Pfam (PF00856) UniProt (by SIFTS) (Q9NQR1)	HOMO SAPIENS (HUMAN)	HISTONE-LYSINE METHYLTRANSFERASE PR-SET7
2	B, D (B, F)	HISTONE H4	polymer	10	1374.6	2	UniProt (P62805) UniProt (by SIFTS) (Q6GMV2)	HOMO SAPIENS
3	E, F (A, E)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	2	Chemie (SAH)
4	G, H, I, J (A, B, E, F)	water	water		18.0	613	Chemie (HOH)

Sequence modifications

A, E: 192 - 352 (UniProt: Q86W83)

PDB	External Database	Details
Pro 316	Arg 316	conflict

B, F: 17 - 25 (UniProt: P62805)
B, F: 26 - 26 (PDB: 2BQZ)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	39522.8
Non-Polymers*	Number of molecules	2
	Total formula weight	768.8
All*	Total formula weight	40291.6

*Water molecules are not included.