2BNR

Structural and kinetic basis for heightened immunogenicity of T cell vaccines

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	HLA CLASS I HISTOCOMPATIBILITY ANTIGEN	polymer	276	31951.3	1	UniProt (P01892) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (P04439)	HOMO SAPIENS (HUMAN)	MHC, A-2 ALPHA CHAIN PRECURSOR
2	B (B)	BETA-2-MICROGLOBULIN	polymer	100	11879.4	1	UniProt (P61769) Pfam (PF07654)	HOMO SAPIENS (HUMAN)	HDCMA22P, B2M
3	C (C)	SYNTHETIC PEPTIDE	polymer	9	1094.3	1	UniProt (by SIFTS) (P78358)	HOMO SAPIENS
4	D (D)	T-CELL RECEPTOR ALPHA CHAIN V REGION	polymer	203	22171.5	1	Pfam (PF07686) Pfam (PF09291) UniProt (by SIFTS) (A0A0B4J279) UniProt (by SIFTS) (P01848)	HOMO SAPIENS (HUMAN)
5	E (E)	T-CELL RECEPTOR BETA CHAIN C REGION	polymer	241	27006.0	1	UniProt (P01850) Pfam (PF07686) Pfam (PF07654) UniProt (by SIFTS) (A0A0K0K1A5)	HOMO SAPIENS (HUMAN)	TRBC1
6	F, G, H, I, J (A, B, C, D, E)	water	water		18.0	520	Chemie (HOH)

Sequence modifications

B: 0 - 0 (PDB: 2BNR)
B: 1 - 99 (UniProt: P61769)
E: 2 - 112 (PDB: 2BNR)
E: 113 - 242 (UniProt: P01850)

PDB	External Database	Details
Lys 116	Asn 4	conflict
Asn 117	Lys 5	conflict
Tyr 149	Phe 37	conflict
Cys 169	Ser 57	conflict
Ala 187	Cys 75	conflict
Asp 201	Asn 89	conflict

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	94102.5
All*	Total formula weight	94102.5

*Water molecules are not included.