2BL9
X-ray crystal structure of Plasmodium vivax dihydrofolate reductase in complex with pyrimethamine and its derivative
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE | polymer | 238 | 27111.0 | 1 | UniProt (Q9U0E8) Pfam (PF00186) UniProt (by SIFTS) (O02604) | PLASMODIUM VIVAX | DIHYDROFOLATE REDUCTASE |
| 2 | B (A) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 3 | C (A) | 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE | non-polymer | 248.7 | 1 | Chemie (CP6) | |||
| 4 | D (A) | water | water | 18.0 | 266 | Chemie (HOH) |
Sequence modifications
A: 1 - 237 (UniProt: Q9U0E8)
A: 238 - 238 (PDB: 2BL9)
| PDB | External Database | Details |
|---|---|---|
| Asn 3 | Asp 3 | conflict |
| Cys 16 | Arg 16 | conflict |
| Ala 24 | Glu 24 | conflict |
| Pro 33 | Leu 33 | conflict |
| Glu 213 | Gln 213 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 27111.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 994.1 | |
| All* | Total formula weight | 28105.1 |
