2BKZ

STRUCTURE OF CDK2-CYCLIN A WITH PHA-404611

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	CELL DIVISION PROTEIN KINASE 2	polymer	309	35251.9	2	UniProt (P24941) Pfam (PF00069) In PDB	HOMO SAPIENS (HUMAN)	P33 PROTEIN KINASE
2	B, D	CYCLIN A2	polymer	265	30279.0	2	UniProt (P20248) Pfam (PF00134) Pfam (PF02984) In PDB	HOMO SAPIENS (HUMAN)	CYCLIN A
3	A, C	1-[4-(AMINOSULFONYL)PHENYL]-1,6-DIHYDROPYRAZOLO[3,4-E]INDAZOLE-3-CARBOXAMIDE	non-polymer		356.4	2	Chemie (SBC)
4	A, D	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
5		water	water		18.0	272	Chemie (HOH)

Sequence modifications

A, C: -4 - 0 (PDB: 2BKZ)
A, C: 299 - 304 (PDB: 2BKZ)
A, C: 1 - 298 (UniProt: P24941)
B, D: 168 - 173 (PDB: 2BKZ)
B, D: 174 - 432 (UniProt: P20248)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	131061.7
Non-Polymers*	Number of molecules	4
	Total formula weight	904.8
All*	Total formula weight	131966.5

*Water molecules are not included.