2BIM
human p53 core domain mutant M133L-V203A-N239Y-N268D-R273H
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | CELLULAR TUMOR ANTIGEN P53 | polymer | 219 | 24571.8 | 2 | UniProt (P04637) Pfam (PF00870) | HOMO SAPIENS (HUMAN) | TUMOUR SUPPRESSOR P53, PHOSPHOPROTEIN P53, ANTIGEN NY-CO-13 |
| 2 | C, E (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, F (A, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 386 | Chemie (HOH) |
Sequence modifications
A, B: 94 - 312 (UniProt: P04637)
| PDB | External Database | Details |
|---|---|---|
| Leu 133 | Met 133 | engineered mutation |
| Ala 203 | Val 203 | engineered mutation |
| Tyr 239 | Asn 239 | engineered mutation |
| Asp 268 | Asn 268 | engineered mutation |
| His 273 | Arg 273 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 49143.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 322.9 | |
| All* | Total formula weight | 49466.5 |
