2BEU
Reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT | polymer | 400 | 45571.1 | 1 | UniProt (P12694) Pfam (PF00676) | HOMO SAPIENS (HUMAN) | BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE E1 COMPONENT ALPHA CHAIN, BCKDH E1-ALPHA, BCKDE1A |
| 2 | B (B) | 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT | polymer | 342 | 37902.3 | 1 | UniProt (P21953) Pfam (PF02779) Pfam (PF02780) | HOMO SAPIENS (HUMAN) | BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE E1 COMPONENT BETA CHAIN, BCKDH E1-BETA |
| 3 | C (C) | PEPTIDE ALA-TYR-ARG | polymer | 3 | 409.5 | 1 | SYNTHETIC CONSTRUCT | ||
| 4 | D, E (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | F (A) | C2-1-HYDROXY-3-METHYL-PROPYL-THIAMIN DIPHOSPHATE | non-polymer | 496.4 | 1 | Chemie (THV) | |||
| 6 | G, K (A, B) | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
| 7 | H (A) | MANGANESE (II) ION | non-polymer | 54.9 | 1 | Chemie (MN) | |||
| 8 | I (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 9 | J (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 10 | L, M, N (A, B, C) | water | water | 18.0 | 505 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 83882.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 888.6 | |
| All* | Total formula weight | 84771.4 |
