2BEL

Structure of human 11-beta-hydroxysteroid dehydrogenase in complex with NADP and carbenoxolone

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	CORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1	polymer	283	31106.0	4	UniProt (P28845) Pfam (PF00106) In PDB	HOMO SAPIENS (HUMAN)	HUMAN 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1,11-DH, 11-BETA-HSD1
2	A, B, C, D	NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		743.4	4	Chemie (NAP)
3	A, B, C, D	CARBENOXOLONE	non-polymer		570.8	4	Chemie (CBO)
4	A, B, C, D	CHLORIDE ION	non-polymer		35.5	4	Chemie (CL)
5		water	water		18.0	268	Chemie (HOH)

Sequence modifications

A, B, C, D: 4 - 25 (PDB: 2BEL)
A, B, C, D: 285 - 286 (PDB: 2BEL)
A, B, C, D: 26 - 284 (UniProt: P28845)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	124423.9
Non-Polymers*	Number of molecules	12
	Total formula weight	5398.5
All*	Total formula weight	129822.3

*Water molecules are not included.