2B7Z

Structure of HIV-1 protease mutant bound to indinavir

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (B, A)	HIV-1 protease	polymer	99	10831.7	2	UniProt (P03367) Pfam (PF00077)	Human immunodeficiency virus 1
2	C (B)	N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE	non-polymer		613.8	1	Chemie (MK1)
3	D, E (B, A)	water	water		18.0	90	Chemie (HOH)

Sequence modifications

B, A: 1 - 99 (UniProt: P03367)

PDB	External Database	Details
Arg 20	Lys 519	engineered mutation
Ile 32	Val 531	engineered mutation
Phe 33	Leu 532	engineered mutation
Ile 36	Met 535	engineered mutation
Ile 46	Met 545	engineered mutation
Pro 63	Leu 562	engineered mutation
Val 71	Ala 570	engineered mutation
Ala 82	Val 581	engineered mutation
Val 84	Ile 583	engineered mutation
Met 90	Leu 589	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	21663.4
Non-Polymers*	Number of molecules	1
	Total formula weight	613.8
All*	Total formula weight	22277.2

*Water molecules are not included.