2B60
Structure of HIV-1 protease mutant bound to Ritonavir
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Gag-Pol polyprotein | polymer | 99 | 10863.8 | 2 | UniProt (Q7SMT3) Pfam (PF00077) | Human immunodeficiency virus 1 | |
| 2 | C (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 3 | D (B) | RITONAVIR | non-polymer | 720.9 | 1 | BIRD (PRD_001001) Chemie (RIT) | |||
| 4 | E, F (A, B) | water | water | 18.0 | 75 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: Q7SMT3)
| PDB | External Database | Details |
|---|---|---|
| Arg 20 | Lys 519 | engineered mutation |
| Ile 32 | Val 531 | engineered mutation |
| Phe 33 | Leu 532 | engineered mutation |
| Ile 36 | Met 535 | engineered mutation |
| Pro 63 | Leu 562 | engineered mutation |
| Val 71 | Ala 570 | engineered mutation |
| Ala 82 | Val 581 | engineered mutation |
| Met 90 | Leu 589 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21727.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 813.0 | |
| All* | Total formula weight | 22540.6 |
