2B0M

Human dihydroorotate dehydrogenase bound to a novel inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Dihydroorotate dehydrogenase, mitochondrial	polymer	393	43009.9	1	UniProt (Q02127) Pfam (PF01180)	Homo sapiens (human)	Dihydroorotate oxidase; DHOdehase
2	B (A)	3-AMIDO-5-BIPHENYL-BENZOIC ACID	non-polymer		317.3	1	Chemie (201)
3	C (A)	FLAVIN MONONUCLEOTIDE	non-polymer		456.3	1	Chemie (FMN)
4	D (A)	OROTIC ACID	non-polymer		156.1	1	Chemie (ORO)
5	E (A)	water	water		18.0	141	Chemie (HOH)

Sequence modifications

A: 30 - 396 (UniProt: Q02127)

PDB	External Database	Details
Met 4	-	expression tag
Gly 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
His 11	-	expression tag
His 12	-	expression tag
His 13	-	expression tag
His 14	-	expression tag
His 15	-	expression tag
Ser 16	-	expression tag
Ser 17	-	expression tag
Gly 18	-	expression tag
His 19	-	expression tag
Ile 20	-	expression tag
Asp 21	-	expression tag
Asp 22	-	expression tag
Asp 23	-	expression tag
Asp 24	-	expression tag
Lys 25	-	expression tag
His 26	-	expression tag
Met 27	-	expression tag
Leu 28	-	expression tag
Glu 29	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	43009.9
Non-Polymers*	Number of molecules	3
	Total formula weight	929.8
All*	Total formula weight	43939.7

*Water molecules are not included.