2AW2

Crystal structure of the human BTLA-HVEM complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, X	B and T lymphocyte attenuator	polymer	120	14101.8	2	UniProt (Q7Z6A9) In PDB	Homo sapiens (human)	B and T lymphocyte-associated protein
2	B, Y	Tumor necrosis factor receptor superfamily member 14	polymer	108	11451.1	2	UniProt (Q92956) Pfam (PF00020) In PDB	Homo sapiens (human)	Herpesvirus entry mediator A, Tumor necrosis factor receptor-like 2, TR2
3	C	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
4	D	beta-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		367.3	1	In PDB GlyTouCan (G61843VN)
5	A	NICKEL (II) ION	non-polymer		58.7	1	Chemie (NI)
6		water	water		18.0	4	Chemie (HOH)

Sequence modifications

A, X: 26 - 137 (UniProt: Q7Z6A9)

PDB	External Database	Details
His 138	-	expression tag
His 139	-	expression tag
His 140	-	expression tag
His 141	-	expression tag
His 142	-	expression tag
His 143	-	expression tag
His 144	-	expression tag
His 145	-	expression tag

B, Y: 1 - 104 (UniProt: Q92956)

PDB	External Database	Details
Gly -3	-	cloning artifact
Ser -2	-	cloning artifact
His -1	-	cloning artifact
Met 0	-	cloning artifact

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	51105.8
Branched	Number of molecules	2
	Total formula weight	791.8
Non-Polymers*	Number of molecules	1
	Total formula weight	58.7
All*	Total formula weight	51956.3

*Water molecules are not included.