2AUH
Crystal structure of the Grb14 BPS region in complex with the insulin receptor tyrosine kinase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Insulin receptor | polymer | 306 | 35033.7 | 1 | UniProt (P06213) Pfam (PF07714) | Homo sapiens (human) | IR, CD220 antigen |
| 2 | B (B) | Growth factor receptor-bound protein 14 | polymer | 59 | 6326.1 | 1 | UniProt (Q14449) Pfam (PF08947) | Homo sapiens (human) | GRB14 adaptor protein |
| 3 | C, D (A) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) |
Sequence modifications
A: 978 - 1283 (UniProt: P06213)
B: 373 - 419 (UniProt: Q14449)
| PDB | External Database | Details |
|---|---|---|
| Ptr 1158 | Tyr 1185 | modified residue |
| Ptr 1162 | Tyr 1189 | modified residue |
| Ptr 1163 | Tyr 1190 | modified residue |
| Asn 1251 | Lys 1278 | variant |
| Ser 981 | Cys 1008 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 411 | Cys 411 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 41359.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 80.2 | |
| All* | Total formula weight | 41439.9 |
