2AR5

Crystal structure of the mammalian C2alpha-PI3 Kinase PX-domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Phosphoinositide 3-kinase	polymer	121	14375.6	1	UniProt (Q14CQ9) Pfam (PF00787) UniProt (by SIFTS) (O00443) In PDB	Homo sapiens (human)	Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide, Phosphoinositide 3-Kinase-C2-alpha, PtdIns-3-kinase C2 alpha, PI3K-C2alpha
2	A	GLYCEROL	non-polymer		92.1	6	Chemie (GOL)
3		water	water		18.0	92	Chemie (HOH)

Sequence modifications

A: 2 - 113 (UniProt: Q14CQ9)

PDB	External Database	Details
Met 1	-	cloning artifact
Gly 114	-	cloning artifact
Ser 115	-	cloning artifact
His 116	-	expression tag
His 117	-	expression tag
His 118	-	expression tag
His 119	-	expression tag
His 120	-	expression tag
His 121	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	14375.6
Non-Polymers*	Number of molecules	6
	Total formula weight	552.6
All*	Total formula weight	14928.1

*Water molecules are not included.