2AR5
Crystal structure of the mammalian C2alpha-PI3 Kinase PX-domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Phosphoinositide 3-kinase | polymer | 121 | 14375.6 | 1 | UniProt (Q14CQ9) Pfam (PF00787) UniProt (by SIFTS) (O00443) | Homo sapiens (human) | Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide, Phosphoinositide 3-Kinase-C2-alpha, PtdIns-3-kinase C2 alpha, PI3K-C2alpha |
| 2 | B, C, D, E, F... (A) | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
| 3 | H (A) | water | water | 18.0 | 92 | Chemie (HOH) |
Sequence modifications
A: 2 - 113 (UniProt: Q14CQ9)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | cloning artifact |
| Gly 114 | - | cloning artifact |
| Ser 115 | - | cloning artifact |
| His 116 | - | expression tag |
| His 117 | - | expression tag |
| His 118 | - | expression tag |
| His 119 | - | expression tag |
| His 120 | - | expression tag |
| His 121 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 14375.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 552.6 | |
| All* | Total formula weight | 14928.1 |
