2AQB
Structure-activity relationships at the 5-position of thiolactomycin: an intact 5(R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherchia coli
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | 3-oxoacyl-[acyl-carrier-protein] synthase I | polymer | 406 | 42656.2 | 4 | UniProt (P0A953) Pfam (PF00109) Pfam (PF02801) In PDB | Escherichia coli | Beta- ketoacyl-ACP synthase I, KAS I |
2 | A, B, D | (5R)-5-[(1E)-BUTA-1,3-DIENYL]-4-HYDROXY-3,5-DIMETHYLTHIOPHEN-2(5H)-ONE | non-polymer | 196.3 | 3 | Chemie (TL6) | |||
3 | water | water | 18.0 | 537 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 170624.8 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 588.8 | |
All* | Total formula weight | 171213.6 |