2AQ7

Structure-activity relationships at the 5-posiiton of thiolactomycin: an intact 5(R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	3-oxoacyl-[acyl-carrier-protein] synthase I	polymer	406	42656.2	4	UniProt (P0A953) Pfam (PF00109) Pfam (PF02801) In PDB	Escherichia coli	Beta- ketoacyl-ACP synthase I, KAS I
2	A, B, D	(5R)-4-HYDROXY-3,5-DIMETHYL-5-[(1E,3E)-2-METHYLPENTA-1,3-DIENYL]THIOPHEN-2(5H)-ONE	non-polymer		224.3	3	Chemie (TL5)
3		water	water		18.0	538	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	170624.8
Non-Polymers*	Number of molecules	3
	Total formula weight	673.0
All*	Total formula weight	171297.8

*Water molecules are not included.