2AOH
Crystal structure analysis of HIV-1 Protease mutant V82A with a substrate analog P6-PR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | POL POLYPROTEIN | polymer | 99 | 10712.6 | 2 | UniProt (P04587) Pfam (PF00077) | Human immunodeficiency virus type 1 (BH5 ISOLATE) | RETROPEPSIN |
| 2 | C (C) | PEPTIDE INHIBITOR | polymer | 10 | 1093.3 | 1 | |||
| 3 | D (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 4 | E, F (B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | G, H, I (A, B, C) | water | water | 18.0 | 240 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P04587)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 75 | engineered mutation |
| Ile 33 | Leu 101 | engineered mutation |
| Ile 63 | Leu 131 | engineered mutation |
| Ala 67 | Cys 135 | engineered mutation |
| Ala 82 | Val 150 | engineered mutation |
| Ala 95 | Cys 163 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 22518.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 93.9 | |
| All* | Total formula weight | 22612.4 |
