2AOB
Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Growth factor receptor-bound protein 2 | polymer | 99 | 11575.2 | 4 | UniProt (P62993) Pfam (PF00017) In PDB | Homo sapiens (human) | GRB2 adapter protein, SH2/SH3 adapter GRB2, Ash protein |
| 2 | A, B, C, D | 2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC ACID | non-polymer | 754.8 | 12 | Chemie (S1S) | |||
| 3 | water | water | 18.0 | 373 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 46300.6 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 9057.9 | |
| All* | Total formula weight | 55358.5 |
