2AOA
Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Growth factor receptor-bound protein 2 | polymer | 99 | 11575.2 | 2 | UniProt (P62993) Pfam (PF00017) | Homo sapiens (human) | GRB2 adapter protein, SH2/SH3 adapter GRB2, Ash protein |
| 2 | C, D, E (A, B) | 2-(4-((9S,10S,14S,Z)-18-(2-AMINO-2-OXOETHYL)-9-(CARBOXYMETHYL)-14-(NAPHTHALEN-1-YLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL)PHENYL)MALONIC ACID | non-polymer | 754.8 | 3 | Chemie (S1S) | |||
| 3 | F (B) | 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL | non-polymer | 326.4 | 1 | Chemie (P33) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 103 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 23150.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2590.9 | |
| All* | Total formula weight | 25741.2 |
