2ANY
Expression, Crystallization and the Three-dimensional Structure of the Catalytic Domain of Human Plasma Kallikrein: Implications for Structure-Based Design of Protease Inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | plasma kallikrein, light chain | polymer | 241 | 27144.8 | 1 | UniProt (P03952) Pfam (PF00089) | Homo sapiens (human) | Kininogenin; Fletcher factor |
| 2 | B, C, D (A) | PHOSPHATE ION | non-polymer | 95.0 | 3 | Chemie (PO4) | |||
| 3 | E (A) | BENZAMIDINE | non-polymer | 120.2 | 1 | Chemie (BEN) | |||
| 4 | F (A) | water | water | 18.0 | 414 | Chemie (HOH) |
Sequence modifications
A: 16 - 248 (UniProt: P03952)
| PDB | External Database | Details |
|---|---|---|
| Glu 21 | Asn 396 | engineered mutation |
| Glu 72 | Asn 453 | engineered mutation |
| Glu 113 | Asn 494 | engineered mutation |
| Ser 122 | Cys 503 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 27144.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 405.1 | |
| All* | Total formula weight | 27549.9 |
