2AH9
Crystal Structure of Human M340H-Beta-1,4-Galactosyltransferase-I (M340H-B4Gal-T1) in Complex with Chitotriose
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C | Beta-1,4-galactosyltransferase 1 | polymer | 287 | 32773.2 | 3 | UniProt (P15291) Pfam (PF13733) Pfam (PF02709) In PDB | Homo sapiens (human) | Beta-1,4-GalTase 1; Beta4Gal-T1; b4Gal-T1; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1 |
2 | D, E, F | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 627.6 | 3 | In PDB BIRD (PRD_900017) GlyTouCan (G47362BJ) | triacetyl-beta-chitotriose | ||
3 | C, A, B | 6-AMINOHEXYL-URIDINE-C1,5'-DIPHOSPHATE | non-polymer | 503.3 | 3 | Chemie (UDH) | |||
4 | C, A, B | MANGANESE (II) ION | non-polymer | 54.9 | 3 | Chemie (MN) | |||
5 | C, A, B | GLYCEROL | non-polymer | 92.1 | 7 | Chemie (GOL) | |||
6 | B, C, A | SULFATE ION | non-polymer | 96.1 | 16 | Chemie (SO4) | |||
7 | C, A | 1,4-DIETHYLENE DIOXIDE | non-polymer | 88.1 | 2 | Chemie (DIO) | |||
8 | C | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
9 | water | water | 18.0 | 548 | Chemie (HOH) |
Sequence modifications
A, B, C: 126 - 398 (UniProt: P15291)
PDB | External Database | Details |
---|---|---|
Ala 112 | - | SEE REMARK 999 |
Ser 113 | - | SEE REMARK 999 |
Met 114 | - | SEE REMARK 999 |
Thr 115 | - | SEE REMARK 999 |
Gly 116 | - | SEE REMARK 999 |
Gly 117 | - | SEE REMARK 999 |
Gln 118 | - | SEE REMARK 999 |
Gln 119 | - | SEE REMARK 999 |
Met 120 | - | SEE REMARK 999 |
Gly 121 | - | SEE REMARK 999 |
Arg 122 | - | SEE REMARK 999 |
Gly 123 | - | SEE REMARK 999 |
Ser 124 | - | SEE REMARK 999 |
Ala 125 | - | SEE REMARK 999 |
Thr 337 | Arg 336 | engineered mutation |
Thr 338 | Cys 337 | engineered mutation |
His 340 | Met 339 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 98319.7 | |
Branched | Number of molecules | 3 |
Total formula weight | 1882.8 | |
Non-Polymers* | Number of molecules | 32 |
Total formula weight | 4227.9 | |
All* | Total formula weight | 104430.4 |