2AH9
Crystal Structure of Human M340H-Beta-1,4-Galactosyltransferase-I (M340H-B4Gal-T1) in Complex with Chitotriose
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Beta-1,4-galactosyltransferase 1 | polymer | 287 | 32773.2 | 3 | UniProt (P15291) Pfam (PF13733) Pfam (PF02709) | Homo sapiens (human) | Beta-1,4-GalTase 1; Beta4Gal-T1; b4Gal-T1; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1 |
| 2 | D, E, F (D, E, F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 627.6 | 3 | In PDB BIRD (PRD_900017) GlyTouCan (G47362BJ) | triacetyl-beta-chitotriose | ||
| 3 | CA, G, P (C, A, B) | 6-AMINOHEXYL-URIDINE-C1,5'-DIPHOSPHATE | non-polymer | 503.3 | 3 | Chemie (UDH) | |||
| 4 | DA, H, Q (C, A, B) | MANGANESE (II) ION | non-polymer | 54.9 | 3 | Chemie (MN) | |||
| 5 | EA, I, J, R, S... (C, A, B) | GLYCEROL | non-polymer | 92.1 | 7 | Chemie (GOL) | |||
| 6 | AA, BA, FA, GA, HA... (B, C, A) | SULFATE ION | non-polymer | 96.1 | 16 | Chemie (SO4) | |||
| 7 | KA, O (C, A) | 1,4-DIETHYLENE DIOXIDE | non-polymer | 88.1 | 2 | Chemie (DIO) | |||
| 8 | LA (C) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 9 | MA, NA, OA (A, B, C) | water | water | 18.0 | 548 | Chemie (HOH) |
Sequence modifications
A, B, C: 126 - 398 (UniProt: P15291)
| PDB | External Database | Details |
|---|---|---|
| Ala 112 | - | SEE REMARK 999 |
| Ser 113 | - | SEE REMARK 999 |
| Met 114 | - | SEE REMARK 999 |
| Thr 115 | - | SEE REMARK 999 |
| Gly 116 | - | SEE REMARK 999 |
| Gly 117 | - | SEE REMARK 999 |
| Gln 118 | - | SEE REMARK 999 |
| Gln 119 | - | SEE REMARK 999 |
| Met 120 | - | SEE REMARK 999 |
| Gly 121 | - | SEE REMARK 999 |
| Arg 122 | - | SEE REMARK 999 |
| Gly 123 | - | SEE REMARK 999 |
| Ser 124 | - | SEE REMARK 999 |
| Ala 125 | - | SEE REMARK 999 |
| Thr 337 | Arg 336 | engineered mutation |
| Thr 338 | Cys 337 | engineered mutation |
| His 340 | Met 339 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 98319.7 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1882.8 | |
| Non-Polymers* | Number of molecules | 32 |
| Total formula weight | 4227.9 | |
| All* | Total formula weight | 104430.4 |
